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Acomplia attacks and reduces a person's urge or craving to eat more. Acomplia has the active ingredient Rimonabant which works directly on the Endocannabinoid system. This system affects energy balance, glucose and lipid metabolism in addition to weight in the human body. Rimonabant blocks certain receptors in this system known as cannabinoid receptors and thereby creates a feeling of false fullness in the person on Accomplia. As a result the person will eat less. When used in conjunction with a calorie reduced diet and regular exercise, Acomplia will lead to significant weight loss in obese patients. Exhaustive clinical trials conducted with Acomplia on more than 6800 patients yielded substantial results. Patients given Accomplia for a period of one year achieved an average weight loss of six and half kg as compared to just over one and half kg achieved by those on placebo. Most of the weight loss was achieved in the first 9 months of the trial with Acomplia. Acomplia was also found to reduce the risk of regaining weight. When a group of patients from one of the clinical trials was re-randomized and split into Acomplia and placebo groups, those patients who continued on Acomplia achieved a total weight loss of 7.5 kg over the two year trial period. On the other hand patients who were transferred to placebo achieved a much lower weight loss of only 3.1 kg over the same period. The best part about Acomplia is that it brings about sizeable reduction in the waist ...
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Generic name: Rimonabant Description: Diet pill Acomplia (Rimonabant) is a miraculous multifunctional pill that helps you short out obesity as well as smoking. Acomplia diet pills work on the Endocannabinoid system, which controls appetite and energy expenditure (as well as the urge to smoke). This wonder pill selectively blocks some receptors in the Endocannabinoid system, thus creating a better balance which in turn suppresses appetite and the longing to overeat. Synonyms: Slimona How does Acomplia work? * Acomplia acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle1. * * Acomplia switches off the same brain circuits that make people hungry when they smoke cannabis. * CB1 receptor blockade with Acomplia acts to decrease the overactivity of the endocannabinoid system (EC system)2,3. The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism. www.4rx.ca
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How does Acomplia work? * Acomplia acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle1. * * Acomplia switches off the same brain circuits that make people hungry when they smoke cannabis. * CB1 receptor blockade with Acomplia acts to decrease the overactivity of the endocannabinoid system (EC system)2,3. The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism. What is Acomplia used for? * Acomplia is used complementary to diet and exercise to treat obese or overweight patients who suffer from Type 2 diabetes and abnormal levels of fat in the blood. * Sanofi argues that Acomplia can also prevent the risk of cardiovascular disease. * Patients with large waist circumference (102 cm in men and 88 cm in women) will mostly benefit from taking the drug. What are the side-effects of Acomplia? * Side effects in the trial on Acomplia in obesity were vomiting and nausea, forcing about 19 percent of patients to leave the trial versus 13 percent of those who took placebo. www.4rx.ca
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How does Acomplia work? * Acomplia acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle1. * * Acomplia switches off the same brain circuits that make people hungry when they smoke cannabis. * CB1 receptor blockade with Acomplia acts to decrease the overactivity of the endocannabinoid system (EC system)2,3. The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism. What is Acomplia used for? * Acomplia is used complementary to diet and exercise to treat obese or overweight patients who suffer from Type 2 diabetes and abnormal levels of fat in the blood. * Sanofi argues that Acomplia can also prevent the risk of cardiovascular disease. * Patients with large waist circumference (102 cm in men and 88 cm in women) will mostly benefit from taking the drug. www.4rx.ca
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From Cleveland - The weight loss drug Acomplia may alter certain risk factors for heart disease, but doesn't appear to reverse it. Researchers randomized over 800 patients who required an angiogram to receive either Acomplia or placebo. Using intravascular ultrasound, no differences were noted in those who received the two treatments. Those who received Acomplia lost more weight and had a greater reduction in triglycerides, but were also more likely to develop psychiatric symptoms. From Texas - The American Heart Association has officially recognized that "hands only" CPR, a technique in which no breaths are administered and instead 100 compressions per minute are delivered, is superior to the traditional technique. The traditional technique is still recommended for children, given that a collapse in a child is more likely due to a breathing problem. And finally, from Hamilton - A newer class of blood pressure lowering medications known as ARBs may have a better safety profile than older ones. A trial of over 25000 patients with heart disease were randomized to receive an ARB, an ACE inhibitor or both. Those who received an ARB or an ACE inhibitor had an equal lowering effect on blood pressure, but those who received the ARB were less likely to experience side effects. For Insidermedicine in 60, I'm Dr. Susan Sharma.
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July 20, 2007 (Insidermedicine) From California, A few grey hairs may not be bad for drivers. A study from the RAND corporation shows that drivers between the ages of 15 to 24 are 3 times more likely cause a car crash than those who 65 or older. Despite making up 15% of the population, seniors accounted for only 7% of crashes. From Maryland, The FDA is warning consumers not to eat certain brands of canned chili sauce because of the risk botulism- a potentially fatal condition. A couple in Indiana and two children in Texas are seriously ill in hospital after eating affected products. The warning includes a number of sauces made by Castleberry's. From London, Those on Acomplia- the weight loss drug- should monitor for symptoms of depression. The EMEA- the European equivalent of the FDA- is recommending stronger wording on the product label, warning of potential psychiatric side effects- including suicide. They recommend not taking the drug if you are are on antidepressants. And finally also from the UK, Tennis players beware; serious low back injuries are a problem in elite tennis players. Researchers noted problems on the MRIs of over 85% of the players. Problems included spinal disc degeneration, herniated discs, and stress fractures. For Insidermedicine in 60, I'm Dr. Susan Sharma.
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A diet drug that has generated some news is the French drug called "Acomplia Rimonabant." The anti-obesity drug, an appetite suppressant, was created to help people lose fat by blocking circuitry in the brain that gives the body cravings. The drug works by an entirely new approach by blocking the same primeval circuitry in the brain that gives pot-smokers the munchies. The French firm Sanofi-Synthelabo won approval to market it in the European Union in 2006. It is not yet approved in the US, where it is known as "Zimulti". A study found that the drug helped people drop 20 pounds in a year. Doctors say the drug is noteworthy because it takes a different approach to helping people overcome their cravings for food. It is the first of a class of medicines that blocks the so-called endocannabinoid system in the central nervous system. Marijuana makes people hungry by stimulating this circuitry. The same biology serves crucial everyday purposes by helping the brain regulate hunger, including alcohol craving. Overeating can overstimulate this system, which in turn causes people to eat and smoke more. By temporarily blocking the body's ability to receive these signals, experts believe they can return the system to normal. In the larger of the two studies, Dr. Jean-Pierre Despres of Laval University in Quebec City used 1036 volunteers, all with stomachs that put them at high risk for heart problems. They were urged to cut 600 calories/day and given either accomplia or placebos ...
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